Can Prescription Medications Affect Testosterone Levels?

September 2023

African American male in his 50'sCan prescription medications have an impact on testosterone levels? Absolutely! Some prescription medications can potentially lead to a decrease in testosterone levels. Let’s take a closer look at a few examples:

Ketoconazole (Extina, Nizoral, Ketoderm): This medication is typically used to treat fungal or yeast infections, such as athlete’s foot, seborrheic dermatitis, or dandruff. It’s available in various forms like pills, creams, foams, gels, or shampoos.

Cimetidine (Tagamet): Often prescribed for individuals with ulcers or gastroesophageal reflux disease (GERD), cimetidine is also used as an over-the-counter remedy for heartburn. It can be found in tablet and liquid forms.

Spironolactone (Aldactone): This medication is commonly used in combination with other drugs to treat high blood pressure and heart failure. Additionally, it may help those with excessive aldosterone (a hormone) or individuals with edema caused by heart, liver, or kidney disease.

Certain antidepressants: Some antidepressants have been associated with lower testosterone levels. It’s crucial to consult with a doctor to determine the most suitable antidepressant option if testosterone levels are a concern.

Chemotherapy drugs: Testosterone levels may be affected by chemotherapy drugs, which can potentially harm the testes responsible for testosterone production.

Additionally, recent studies have explored the impact of other medications on testosterone levels:

Opioids: Pain relievers like morphine, codeine, hydrocodone (Vicodin), and oxycodone (OxyContin, Percocet) fall under this category. There are short-acting and long-acting opioids, with the latter leading to an increased risk of low testosterone levels compared to the former, according to a study published in The Clinical Journal of Pain.

Statins: Prescribed to lower cholesterol, statins have also been found to potentially decrease testosterone levels in both men and women. However, the significance of this effect remains unclear and requires further investigation.

While these medications serve important purposes, it’s essential to be aware of their potential impact on testosterone levels. If you have concerns about testosterone levels, consult with a healthcare professional for personalized advice and guidance.

In recent studies, researchers have delved into the effects of statins on testosterone levels. They have observed a slight decrease in testosterone, although the significance of this effect on patients remains unclear. It is worth noting that normal testosterone levels for men can vary widely, ranging from 300 ng/dL to 800 ng/dL. Consequently, the impact of this decrease may differ from one individual to another. Further research is necessary to fully understand the potential effects of statins.

Meanwhile, there are luckily physicians that have specialized and experience in Hormone Optimization Therapies and Cardio-Metabolic Dysfunctions and would know the best methods to evaluate your situation and work with you to have the best therapy to combat such medication side effects. This starts by advanced knowledge in how to effectively optimize your Testosterone Hormone to combat or even overcome the effects of such medications and also such physicians are usually operate on the side of “ the less need for pharmaceuticals medications, the better” so they would be the ideal help in evaluating for taking you off of certain medications at the appropriate time.

Dr. Payam Kerendian in Los Angeles is one of such physicians with a high referral rate and excellent online reputation. His wait time for original consultation appointments seems to be a little long, but that is a further testament to his reputation and worthwhile treatment methods.